I came across this double-blind randomized controlled study investigating the combined effect of PRP and ultra-pulsed fractional CO2 laser on facial rejuvenation.
Facial rejuvenation has been a hot topic in the field of cosmetic plastic surgery. “A variety of mechanisms causing skin aging have been proven, including declining growth capacity of skin tissue, decreased cell viability, disordered keratinocyte, reduced synthesis of collagen fiber in the dermis layer, and degeneration of elastic fibers.”
Currently, fractional CO2 laser is considered a safe, accurate, and effective treatment for facial rejuvenation promoting not only collagen regeneration and rearrangement and connective tissue synthesis, “but also accelerate tissue recovery by directly vaporizing pigment group or pigment cells, accelerating skin metabolism, and promoting the regeneration of dermis and epidermis, thereby reducing or eliminating mild to moderate wrinkles, improving skin texture and color, shrinking pores, and relieving skin flabbiness, achieving the immediate and long-term effect of firming skin”. PRP plays a vital role in regulating angiogenesis (new blood vessels formation) through secreting a large number of growth factors promoting the soft tissue and collagen regeneration to a greater degree.
Therefore, PRP combined with ultra-pulsed fractional CO2 laser had a synergistic effect on facial rejuvenation and promoting better therapeutic effect leading to more than 84.62% patient satisfaction in facial wrinkles reduction and skin texture improvement. Additionally, there is much faster recovery and less duration of adverse events, such as petechias, pigmentation, effusion, infection, keloid, blisters, and contact dermatitis.
“In my opinion, PRP and fractional CO2 laser should be the standard protocol in the facial rejuvenation model.” Svetlana M. Danovich MD.