WHAT EXACTLY IS WHOLE BODY ORGANIC REJUVENATION?
The concept of rejuvenation has been reimagined time and time again. In an effort to increase our knowledge of what it means to experience rejuvenation, we have also solidified what the final definition should be. The growth of digitized interaction of the internet and social media has allowed us to feel confident in our process and sensibility. With a thoughtful exchange of experience, both good and bad, we have been afforded a new outlet for research, understanding, and compassion to take place. This marks a time where it is our obligation to start thinking about the quality of life we deserve. This mentality is not exclusive to just one sector of our livelihood, but rather the entirety of our being. In reality, there should be a certain level of quality in everything we do, because nothing is exempt from the effects of time.
Keeping this in mind, I started thinking about the necessity of what I call “Whole Body Organic Rejuvenation.” This is a modern yet stabilized way of both improving and preserving the body while maintaining a level of comfort that will last forever.
Looking and feeling younger are valuable objectives that start from within. This fact points us towards an internalized mode of systemized thinking and practice that utilizes the organic resources of our bodies. By combining these resources, which include fat, stem cells, and platelet-rich plasma (PRP) derived from your body, the goal of looking fresher, younger, and most importantly natural, becomes attainable. Immunologically compatible entities such as these, combat the use of foreign substances and work together to create long lasting results without the risk of infection.
Whole Body Organic Rejuvenation is a method that seeks to debunk the myth surrounding the aging process. The key to this approach is understanding that aging is not targeted or isolated within one single feature, but instead, affects the entirety of our bodies both inside and out. Through the manipulation of natural material extracted from the body, we can address various signs of aging by counteracting them with materials that are compatible and non-threatening. The goal is to treat our imperfections with resources and practices that are easily accepted by our bodies as opposed to using harsh alternatives that will jeopardize the natural look and function of our physicality. With a comprehensive attitude, we can maintain the beauty of our most important features, such as the face, neck, decollete lines, hands, hair, and even significantly improve our sexual well-being. In order to block the effects of a non-discriminatory fate such as aging, the solution has to be universal as well.
WHAT IS PLATELET-RICH PLASMA, AND WHY WE SHOULD CONSIDER IT?
The first descriptions of the regenerative use of PRP as a strategy for enhancing bone grafts were described in 1998 in oral surgery.
PRP is obtained by centrifugation of the entire blood to get a five to seven times concentration of autologous platelets suspended in small volumes of plasma. Before injection, platelets are activated using calcium chloride and bovine thrombin to trigger degranulation of granules.
Activated platelets then release a variety of growth factors meant to initiate wound healing, including platelet-derived growth factor, transforming growth factor-b1 and 2, vascular endothelial growth factor, thrombospondin, and epidermal growth factor.
PRP has also been used independently for a variety of facial aesthetic procedures, from reducing edema and ecchymosis post facelift to treating facial rhytides.
PRP enhances cellular proliferative and secretory functions, stimulates angiogenesis, and improves fat graft retention.
PRP may also have applications for hair regrowth. A double-blind placebo-controlled randomized controlled trial found that PRP was able to significantly improve hair regrowth in alopecia areata better than either placebo or steroid cream.
By using PRP, we can address sexual problems in women (O-Shot®) and men (P-Shot®). The Orgasm Shot® (O-Shot®) procedure is a very specific method of using platelet-rich plasma to rejuvenate the vagina and help provide relief to women with urinary incontinence and sexual problems. The P-Shot® procedure increases circulation within the penis for a healthier organ which results in stronger and longer lasting erections.
WHAT IS THE BIGGEST ADVANTAGE OF FAT TRANSFER?
Over the course of years, we’ve developed a meticulous, standardized means of processing and injecting lipoaspirate, termed lipostructure. Fat grafting has become widely used in aesthetic surgery. The cells present in lipoaspirate are similar to bone marrow mesenchymal stem cells. These adipose-derived stem cells (ADSCs) have since become one of the most widely used stem cells population in regenerative medicine because of ease of harvest, and diverse differentiation capacity. Those cells have the capacity to differentiate to mesoderm derivatives, including fat, cartilage, muscle, and bone. Furthermore, they can be induced to form endodermal and ectodermal tissue types, including skin epithelium, neural cells, hepatocytes, and pancreatic islets. In addition to their differentiation capacity, stem cells are also involved in paracrine signaling for angiogenesis, immunomodulation, and tissue regeneration.
It has been proven by multiple studies that PRP enhances stem cells proliferation and secretory functions, as well as improving fat graft retention. That is why it’s so imperative to combine both treatments to maximize the effects of rejuvenation in the most modern, scientifically driven, and natural manner!
The applications of fat grafting are diverse, and improvements are well documented. In the context of aesthetics, patients most commonly seek fat grafting to improve aging-related changes to the face, including reduced fullness, skin thinning, loss of elasticity, and sun damage. Because of fat’s ability to restore volume and improve skin quality, it’s ideal for facial rejuvenation. In many cases, fat grafting alone can achieve dramatic effects, but it becomes a particularly powerful technique when used in conjunction with excision of excess skin. Skin quality continues to improve over long-term follow-up. Younger patients may seek fat grafting because of dissatisfaction with facial proportions. Fat grafting has the capacity to achieve aesthetic balance while maintaining a natural appearance, particularly with such features as the jaw line, cheeks, or chin. The minimally invasive nature of fat grafting is ideal compared with alternatives, such as bone grafts, temporary injectables, or solid implants.
The success of antiretroviral therapies and protease inhibitors for the treatment of human immunodeficiency virus has led to an increase in drug-related facial lipodystrophies, marked by buccal and temporal hollowing. Fat grafting can provide an excellent long-term solution for these patients as well.
The regenerative properties of fat, likely caused by the presence of stem cells, make fat grafts useful for more than just volume replacement. This is exemplified by the work of Rigotti and colleagues with radiation injury. Fat grafting essentially cured radiation-related tissue damage in non-healing radiated wounds. Also, there have been numerous reports of improved scar quality after fat grafting. In addition to restoring volume, fat grafting rejuvenated the overlying skin, as evidenced by improvements in texture, contour, and color.